Angelyn Almonte scored 25 points as DePaul, No. 8 in the NJ.com Top 20, went on the road to hold off Wayne Hills, 48-41, in Wayne.
With the win, DePaul improves to a perfect 10-0 on the season.
Kaja Lenczyk paced Wayne Hills (7-6) with 18 points and seven rebounds and Emma Cataline scored 13 points.